Section 3: Genetics, Cellular and Molecular Biology
DNA replication, transcription, translation
Subtopic: Fundamentals of DNA replication, transcription, translation
Question Statement:
Match the antibiotics in Group I with their modes of action in Group II
Group I
Group II
P) Chloramphenicol
1) Inhibits protein synthesis by acting on 30S bosomal subunit
Q) Rifampicin
R) Tetracycline
3) Inhibits protein synthesis by acting on 50S ribosomal subunit
2) Interferes with DNA replication by inhibiting DNA gyrase
S) Quinolone
4) Interferes with RNA polymerase activity
5) Inhibits B-lactamase activity
Options:
(A) P-1, Q-2, R-3, S-5
(B) P-3, Q-4, R-1, S-2
(C) P-3, Q-2, R-1, S-4
(D) P-1, Q-4, R-3, S-2
Official Answer Key:
B
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2015 Q.50)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: BT
- **Question Type**: **MCQ** (2 Marks)
- **Core Topic**: Biochemistry, Microbiology & Molecular Biology
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"--- PAGE 16 ---
Match the antibiotics in Group I with their modes of action in Group II
Group I
Group II
P) Chloramphenicol
1) Inhibits protein synthesis by acting on 30S bosomal subunit
Q) Rifampicin
R) Tetracycline
3) ..."*
- **Option (B) [CORRECT]**: *"P-3, Q-4, R-1, S-2"*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (A) [INCORRECT]**: *"P-1, Q-2, R-3, S-5"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (C) [INCORRECT]**: *"P-3, Q-2, R-1, S-4"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (D) [INCORRECT]**: *"P-1, Q-4, R-3, S-2
Options :
1.
2. V B
3.
C
4.
D"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **B**
- **Scoring Criteria**: 2 Marks (Negative marking: -0.66 marks).
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