Section 4: Bioprocess Engineering and Process Biotechnology
Mass transfer in bioprocesses (kLa)
Subtopic: Fundamentals of Mass transfer in bioprocesses (kLa)
Question Statement:
Match the drugs in Group I with their mechanism of action in Group II.
Group 1
Group I
P) Paclitaxel
1) Inhibits protein translation
Q) Colchicine
2) Inhibits microtubule depolymerization
R) Etoposide
3) Inhibits DNA replication
S) Methotrexate
4) Alkylates DNA
5) Inhibits dihydrofolate reductase
6) Inhibits microtubule polymerization
Options:
(A) P-1, Q-6, R-3, S-4
(B) P-2, Q-6, R-3, S-5
(C) P-1, Q-3, R-6, S-5
(D) P-2, Q-3, R-6, S-4
Official Answer Key:
B
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2015 Q.41)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: BT
- **Question Type**: **MCQ** (2 Marks)
- **Core Topic**: Biochemistry, Microbiology & Molecular Biology
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"Match the drugs in Group I with their mechanism of action in Group II.
Group 1
Group I
P) Paclitaxel
1) Inhibits protein translation
Q) Colchicine
2) Inhibits microtubule depolymerization
R) Etoposide
3) Inhibits DNA rep..."*
- **Option (B) [CORRECT]**: *"P-2, Q-6, R-3, S-5"*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (A) [INCORRECT]**: *"P-1, Q-6, R-3, S-4"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (C) [INCORRECT]**: *"P-1, Q-3, R-6, S-5"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (D) [INCORRECT]**: *"P-2, Q-3, R-6, S-4
Options :
1. *
2.V B
3. * C
4. * D"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **B**
- **Scoring Criteria**: 2 Marks (Negative marking: -0.66 marks).
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