Subtopic: Fundamentals of Downstream processing (chromatography, filtration)
Question Statement:
Which one of the following is INCORRECT about a typical apoptotic cell?
Options:
(A) Phosphatidylserine is presented on the outer cell surface
(B) Cytochrome c is released from mitochondria
(C) Mitochondrial membrane potential does not change
(D) Annexin-V binds to the cell surface
Official Answer Key:
C
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2015 Q.25)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: BT
- **Question Type**: **MCQ** (1 Mark)
- **Core Topic**: Biochemistry, Microbiology & Molecular Biology
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"Which one of the following is INCORRECT about a typical apoptotic cell?..."*
- **Option (C) [CORRECT]**: *"Mitochondrial membrane potential does not change"*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (A) [INCORRECT]**: *"Phosphatidylserine is presented on the outer cell surface"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (B) [INCORRECT]**: *"Cytochrome c is released from mitochondria"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (D) [INCORRECT]**: *"Annexin-V binds to the cell surface
Options :
1. # A
2. * B
3. V C
4. * D
"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **C**
- **Scoring Criteria**: 1 Mark (Negative marking: -0.33 marks).
Practice This in Real CBT Exam Interface
Test yourself with the official TCS-iON palette, virtual calculator, and immediate performance analytics.