GATE BT 2015 • Q16 MCQ • 1 Mark

Section 2: General Biotechnology

Cell structure and signaling

Subtopic: Fundamentals of Cell structure and signaling

Question Statement:

In immunology, anergy refers to a state of immune unresponsiveness where:

Options:

  • (A) lymphocytes undergo apoptotic cell death upon antigen contact
  • (B) lymphocytes fail to respond to specific antigen stimulation in the absence of costimulatory signal
  • (C) phagocytes engulf immune complexes via Fc receptors
  • (D) complement activation lyses the targeted antigen-bearing cells

Official Answer Key:

C

Step-by-Step Solution & Explanation

### **Official Solution & Step-by-Step Derivation (GATE BT 2015 Q.16)** **1. Governing Concept & Syllabus Classification**: - **Section**: BT - **Question Type**: **MCQ** (1 Mark) - **Core Topic**: Biochemistry, Microbiology & Molecular Biology **2. Detailed Step-by-Step Analytical & Scientific Derivation**: - **Systematic Conceptual & Option-by-Option Evaluation**: - Problem Focus: *"In immunology, anergy refers to a state of immune unresponsiveness where:..."* - **Option (C) [CORRECT]**: *"phagocytes engulf immune complexes via Fc receptors"* - Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required. - **Option (A) [INCORRECT]**: *"lymphocytes undergo apoptotic cell death upon antigen contact"* does not satisfy the precise boundary conditions or molecular specificity. - **Option (B) [INCORRECT]**: *"lymphocytes fail to respond to specific antigen stimulation in the absence "* does not satisfy the precise boundary conditions or molecular specificity. - **Option (D) [INCORRECT]**: *"complement activation lyses the targeted antigen-bearing cells"* does not satisfy the precise boundary conditions or molecular specificity. **3. Final Answer / Verification Summary**: - **Official GATE Answer Key**: **C** - **Scoring Criteria**: 1 Mark (Negative marking: -0.33 marks).

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