Subtopic: Fundamentals of Cell structure and signaling
Question Statement:
The active site in the alpha/beta barrel structures is usually located
(A) inside the barrel (B) at the amino side of the strands
(C) at the carboxy side of the strands
(D) at any arbitrary site
Options:
(A) inside the barrel
(B) at the amino side of the strands
(C) at the carboxy side of the strands
(D) at any arbitrary site
Official Answer Key:
C
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2014 Q.55)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: BT
- **Question Type**: **MCQ** (1 Mark)
- **Core Topic**: Biochemistry, Microbiology & Molecular Biology
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"Match the items in Group I with Group II
Group I
Group II
P
Receptor tyrosine kinase
1
Inactivation of G-proteins
Q
Cyclic GMP (cGMP)
2
Reception of insulin signal
R
GTPase activati..."*
- **Option (C) [CORRECT]**: *"P-3, Q-1, R-4, S-2"*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (A) [INCORRECT]**: *"P-1, Q-3, R-4, S-2"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (B) [INCORRECT]**: *"P-2, Q-4, R-3, S-1"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (D) [INCORRECT]**: *"P-2, Q-4, R-1, S-3"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **C**
- **Scoring Criteria**: 1 Mark (Negative marking: -0.33 marks).
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