Subtopic: Fundamentals of Cell structure and signaling
Question Statement:
Match the items in Group I with Group II
Group I Group II
P Receptor tyrosine kinase 1 Inactivation of G-proteins
Q Cyclic GMP (cGMP) 2 Reception of insulin signal
R GTPase activating protein (GAP) 3 Thyroid hormone
S Nuclear receptor 4 Receptor guanylyl cyclase
(A) P-1, Q-3, R-4, S-2 (B) P-2, Q-4, R-3, S-1
(C) P-3, Q-1, R-4, S-2
(D) P-2, Q-4, R-1, S-3
Options:
(A) P-1, Q-3, R-4, S-2
(B) P-2, Q-4, R-3, S-1
(C) P-3, Q-1, R-4, S-2
(D) P-2, Q-4, R-1, S-3
Official Answer Key:
A
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2014 Q.45)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: BT
- **Question Type**: **MCQ** (1 Mark)
- **Core Topic**: Biochemistry, Microbiology & Molecular Biology
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"In a relatively large but finite and closed population of sexually reproducing diploid organisms, the
frequency of homozygous genotype PP changes from 0.40 to 0.50 and that of pp changes from 0.40
to 0.41 in a span of ..."*
- **Option (A) [CORRECT]**: *"Non-random mating"*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (B) [INCORRECT]**: *"Random genetic drift"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (C) [INCORRECT]**: *"Selection"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (D) [INCORRECT]**: *"Combination of non-random mating and random genetic drift"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **A**
- **Scoring Criteria**: 1 Mark (Negative marking: -0.33 marks).
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