GATE BT 2010 • Q38 MCQ • 2 Marks

Section 2: General Biotechnology

Biomolecules, enzyme kinetics

Subtopic: Fundamentals of Biomolecules, enzyme kinetics

Question Statement:

A mutant Ga protein with increased GPase activity would

Options:

  • (A) not bind to GTP
  • (B) not bind to GDP
  • (C) show increased signaling
  • (D) show decreased signaling

Official Answer Key:

C

Step-by-Step Solution & Explanation

### **Official Solution & Step-by-Step Derivation (GATE BT 2010 Q.38)** **1. Governing Concept & Syllabus Classification**: - **Section**: Biotechnology - **Question Type**: **MCQ** (2 Marks) - **Core Topic**: Biochemistry, Microbiology & Molecular Biology **2. Detailed Step-by-Step Analytical & Scientific Derivation**: - **Systematic Conceptual & Option-by-Option Evaluation**: - Problem Focus: *"A mutant Ga protein with increased GPase activity would..."* - **Option (C) [CORRECT]**: *"show increased signaling"* - Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required. - **Option (A) [INCORRECT]**: *"not bind to GTP"* does not satisfy the precise boundary conditions or molecular specificity. - **Option (B) [INCORRECT]**: *"not bind to GDP"* does not satisfy the precise boundary conditions or molecular specificity. - **Option (D) [INCORRECT]**: *"show decreased signaling"* does not satisfy the precise boundary conditions or molecular specificity. **3. Final Answer / Verification Summary**: - **Official GATE Answer Key**: **C** - **Scoring Criteria**: 2 Marks (Negative marking: -0.66 marks).

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