Section 4: Bioprocess Engineering and Process Biotechnology
Mass transfer in bioprocesses (kLa)
Subtopic: Fundamentals of Mass transfer in bioprocesses (kLa)
Question Statement:
Match the chemicals in Group I with the possible type/class in Group II:
Group I:
P. Actinomycin D
Q. Methotrexate
R. 5-Fluorouracil
S. Colchicine
Group II:
1. Dihydrofolate reductase inhibitor
2. Intercalates into DNA and inhibits transcription
3. Microtubule polymerization inhibitor
4. Thymidylate synthase inhibitor
Options:
(A) P-2, Q-1, R-4, S-3
(B) P-4, Q-1, R-2, S-3
(C) P-3, Q-1, R-2, S-4
(D) P-1, Q-4, R-3, S-2
Official Answer Key:
A
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2010 Q.31)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: Biotechnology
- **Question Type**: **MCQ** (2 Marks)
- **Core Topic**: Biochemistry, Microbiology & Molecular Biology
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"Match the chemicals in Group I with the possible type/class in Group II
Group !
Group Il
P. Picloram
Q. Zeatin
2. Auxin
1. Vitamin
R. Thiamine
S. Glutamine
3. Amino Acid
4. Cytokinin..."*
- **Option (A) [CORRECT]**: *""*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (C) [INCORRECT]**: *"P-2. Q-4, R-1. S-3"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (B) [INCORRECT]**: *"P-4. Q-1, R-2, S-3
P-3, Q-1. R-2, 5-4"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (D) [INCORRECT]**: *"PA. Q-2. R-1, S-3
5/16
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20151
B1"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **A**
- **Scoring Criteria**: 2 Marks (Negative marking: -0.66 marks).
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