GATE BT 2010 • Q24
MCQ • 1 Mark
Section 2: General Biotechnology
Biomolecules, enzyme kinetics
Subtopic: Fundamentals of Biomolecules, enzyme kinetics
Question Statement:
Nuclease-hypersensitive sites in the chromosomes are typically
Options:
-
(A) H2A and H2B histone free
-
(B) H3 and H4 histone free
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(C) H1 and H2 histone free
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(D) Nucleosome free
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2010 Q.24)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: Biotechnology
- **Question Type**: **MCQ** (1 Mark)
- **Core Topic**: Biochemistry, Microbiology & Molecular Biology
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"Nuciease-hypersensitive sites in the chromosoines are sites that appear to be..."*
- **Option (C) [CORRECT]**: *"H3 and H4 bistone frec"*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (A) [INCORRECT]**: *"H2 and H4 histone free"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (D) [INCORRECT]**: *"HI and H2 histone free
Nuckcosome frec"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **C**
- **Scoring Criteria**: 1 Mark (Negative marking: -0.33 marks).
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