Subtopic: Fundamentals of Biomolecules, enzyme kinetics
Question Statement:
The degree of inhibition for an enzyme catalyzed reaction at a particular inhibitor concentration is
independent of initial substrate concentration. The inhibition follows
Options:
(A) competitive inhitition
(B) mixed inhibition
(C) un-competitive inhibition
(D) non-competitive inhibition
Official Answer Key:
D
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2010 Q.22)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: Biotechnology
- **Question Type**: **MCQ** (1 Mark)
- **Core Topic**: Biochemistry, Microbiology & Molecular Biology
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"The degree of inhibition for an enzyme catalyzed reaction at a particular inhibitor concentration is
independent of initial substrate concentration. The inhibition follows..."*
- **Option (D) [CORRECT]**: *"non-competitive inhibition"*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (A) [INCORRECT]**: *"competitive inhitition"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (B) [INCORRECT]**: *"mixed inhibition"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (C) [INCORRECT]**: *"un-competitive inhibition"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **D**
- **Scoring Criteria**: 1 Mark (Negative marking: -0.33 marks).
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