GATE BT 2025 • Q45 MCQ • 2 Marks

Section 4: Bioprocess Engineering and Process Biotechnology

Downstream processing (chromatography, filtration)

Subtopic: Fundamentals of Downstream processing (chromatography, filtration)

Question Statement:

Let m and n be fixed real numbers. If the function y(t) = C1et + C2e-t is a solution of d2y dt2 + m dy dt + ny = 0 for any constants C1 and C2, then m + n is equal to

Options:

  • (A) -2
  • (B) -1
  • (C) 0
  • (D) 1

Official Answer Key:

B

Step-by-Step Solution & Explanation

### **Official Solution & Concept Analysis (GATE BT 2025 Q.45)** **1. Governing Concept**: - **Topic**: Downstream Processing & Centrifugal Sedimentation (Stokes' Law) - The terminal settling velocity ($v_g$) of a spherical particle of diameter $d_p$ and density $\rho_p$ in a fluid of density $\rho_f$ and viscosity $\mu$ under gravity is given by **Stokes' Law**: $v_g = \frac{d_p^2 (\rho_p - \rho_f) g}{18 \mu}$ - In a centrifuge with centrifugal acceleration $\omega^2 r = G g$: $v_c = \frac{d_p^2 (\rho_p - \rho_f) \omega^2 r}{18 \mu}$ - Sedimentation velocity is directly proportional to the square of particle diameter ($d_p^2$) and the density difference $(\rho_p - \rho_f)$, and inversely proportional to fluid viscosity ($\mu$). **2. Option Analysis**: - **Option (A) is INCORRECT**: Settling velocity increases with the square of diameter ($d_p^2$), not linearly. - **Option (B) is CORRECT**: Sedimentation velocity is inversely proportional to the liquid viscosity ($\mu$). - **Option (C) is INCORRECT**: Velocity is proportional to the density difference $(\rho_p - \rho_f)$, not the sum. - **Option (D) is INCORRECT**: Settling velocity increases with centrifugal field ($\omega^2 r$), not decreases. **3. Final Answer**: - **Correct Choice**: **B**

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