GATE BT 2023 • Q16 MCQ • 1 Mark

Section 3: Genetics, Cellular and Molecular Biology

DNA replication, transcription, translation

Subtopic: Fundamentals of DNA replication, transcription, translation

Question Statement:

Which one of the following drugs is NOT an immune checkpoint inhibitor?

Options:

  • (A) Ipilimumab
  • (B) Pembrolizumab
  • (C) Nivolumab
  • (D) Trastuzumab

Official Answer Key:

D

Step-by-Step Solution & Explanation

### **Official Solution & Concept Analysis (GATE BT 2023 Q.16)** **1. Governing Concept**: - **Topic**: Immunology & Pharmacotherapy (Immunosuppressants) - Immunosuppressive drugs: - **Cyclosporine A**: Calcineurin inhibitor blocking IL-2 transcription in T-cells (immunosuppressant). - **Tacrolimus (FK506)**: Binds FKBP12, inhibiting calcineurin (immunosuppressant). - **Rapamycin (Sirolimus)**: Inhibits mTOR kinase, blocking T-cell proliferation (immunosuppressant). - **Penicillin**: $\beta$-lactam antibiotic that inhibits bacterial peptidoglycan cell wall transpeptidase; it has **no immunosuppressive activity**. **2. Option Analysis**: - **Option (A) is INCORRECT**: Cyclosporine A is a potent immunosuppressive drug. - **Option (B) is INCORRECT**: Tacrolimus is a potent immunosuppressive drug. - **Option (C) is INCORRECT**: Rapamycin is a potent immunosuppressive drug. - **Option (D) [Penicillin] is CORRECT**: An antibacterial antibiotic, not an immunosuppressive agent. **3. Final Answer**: - **Correct Choice**: **D**

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