Section 4: Bioprocess Engineering and Process Biotechnology
Mass transfer in bioprocesses (kLa)
Subtopic: Fundamentals of Mass transfer in bioprocesses (kLa)
Question Statement:
Match the cell type (Column I) with its function (Column II).
Column I
Column II
P. B cells
1. Humoral immunity
Q. Neutrophils
2. Cytotoxicity
R. T cells
3. Histamine-associated allergy
S. Mast cells
4. Phagocytosis
Options:
(A) P-1, Q-2, R-3, S-4
(B) P-1, Q-4, R-2, S-3
(C) P-4, Q-3, R-1, S-2
(D) P-4, Q-3, R-2, S-1
Official Answer Key:
B
Step-by-Step Solution & Explanation
### **Official Solution & Concept Analysis (GATE BT 2022 Q.38)**
**1. Governing Concept**:
- **Topic**: Immunology & Leukocyte Effector Functions
- Matching immune cell types with primary physiological functions:
- **P. Plasma cells** $\rightarrow$ Terminally differentiated B-cells specialized for high-rate **antibody secretion** $\rightarrow$ **1**
- **Q. Macrophages** $\rightarrow$ Professional antigen-presenting phagocytes that perform **phagocytosis** of pathogens and apoptotic cellular debris $\rightarrow$ **4**
- **R. Cytotoxic T lymphocytes (CD8+ CTLs)** $\rightarrow$ Induce apoptosis in virus-infected and malignant target cells (**cell-mediated cytotoxicity**) via perforin/granzyme $\rightarrow$ **2**
- **S. Mast cells** $\rightarrow$ Granulocytes bearing high-affinity FceRI receptors; undergo **histamine release / degranulation** in Type I allergic hypersensitivity $\rightarrow$ **3**
**2. Option Analysis**:
- **Option (A) is INCORRECT**: Misassigns macrophages to cytotoxicity.
- **Option (B) [P-1, Q-4, R-2, S-3] is CORRECT**: Flawless, canonical matching of all four immune effector lineages.
- **Option (C) is INCORRECT**: Inverts plasma cells and macrophages.
- **Option (D) is INCORRECT**: Misassigns mast cells to antibody secretion.
**3. Final Answer**:
- **Correct Choice**: **B**
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