Subtopic: Fundamentals of Cell structure and signaling
Question Statement:
Match the autoimmune diseases in Group I with the corresponding
primarily affected organ in Group II.
Group I
Group I
P. Hashimoto's disease
1. Brain
Q. Juvenile diabetes
2. Pancreas
R. Multiple sclerosis
3. Skeletal muscle
S. Myasthenia gravis
4. Thyroid
Options:
(A) P-1, Q-2, R-3, S-4
(B) P-3, Q-1, R-2, S-4
(C) P-4, Q-2, R-1, S-3
(D) P-1, Q-2, R-4, S-3
Official Answer Key:
C
Step-by-Step Solution & Explanation
### **Official Solution & Concept Analysis (GATE BT 2021 Q.39)**
**1. Governing Concept**:
- **Topic**: Immunology & Autoimmune Pathophysiology
- Matching autoimmune diseases with their primary target organ:
- **P. Hashimoto's thyroiditis** $\rightarrow$ Autoantibodies against thyroid peroxidase (TPO) and thyroglobulin targeting the **Thyroid gland** $\rightarrow$ **4**
- **Q. Juvenile diabetes (Type 1 Diabetes Mellitus)** $\rightarrow$ Autoimmune destruction of insulin-secreting $\beta$-cells in the **Pancreas** $\rightarrow$ **2**
- **R. Multiple sclerosis** $\rightarrow$ Autoreactive T-cell demyelination of axons in the **Central Nervous System / Brain** $\rightarrow$ **1**
- **S. Myasthenia gravis** $\rightarrow$ Autoantibodies blocking nicotinic acetylcholine receptors at neuromuscular junctions of **Skeletal muscle** $\rightarrow$ **3**
**2. Option Analysis**:
- **Option (A) is INCORRECT**: Misassigns Hashimoto's to brain.
- **Option (B) is INCORRECT**: Misidentifies Juvenile diabetes target.
- **Option (C) [P-4, Q-2, R-1, S-3] is CORRECT**: Accurate matching of organ-specific autoimmune pathologies.
- **Option (D) is INCORRECT**: Swaps thyroid and brain.
**3. Final Answer**:
- **Correct Choice**: **C**
Practice This in Real CBT Exam Interface
Test yourself with the official TCS-iON palette, virtual calculator, and immediate performance analytics.