Subtopic: Fundamentals of Biomolecules, enzyme kinetics
Question Statement:
A protein without its prosthetic group is known as
Options:
(A) apoprotein
(B) hemoprotein
(C) holoprotein
(D) | lipoprotein
Official Answer Key:
A
Step-by-Step Solution & Explanation
### **Official Solution & Concept Analysis (GATE BT 2021 Q.24)**
**1. Governing Concept**:
- **Topic**: Biochemistry & Conjugated Proteins
- Protein structural terminology:
- **Apoprotein (Apoenzyme)**: The protein portion of a conjugated protein that lacks its non-protein prosthetic group or cofactor.
- **Holoprotein (Holoenzyme)**: The fully catalytically active, intact complex consisting of the apoprotein bound to its prosthetic group.
**2. Option Analysis**:
- **Option (A) [apoprotein] is CORRECT**: The polypeptide chain stripped of its prosthetic group.
- **Option (B) [hemoprotein] is INCORRECT**: A protein containing a heme prosthetic group (e.g., hemoglobin).
- **Option (C) [holoprotein] is INCORRECT**: The complete functional protein with prosthetic group attached.
- **Option (D) [lipoprotein] is INCORRECT**: A lipid-conjugated macromolecular complex.
**3. Final Answer**:
- **Correct Choice**: **A**
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