Subtopic: Fundamentals of Biomolecules, enzyme kinetics
Question Statement:
A list of pathogens (Group I) and a list of anti-microbial agents (Group II) used to
treat their infections are given below. Match the pathogens with the corresponding
anti-microbial agents.
Group I
Group II
[P] Influenza A virus
1. Isoniazid
[Q] Fungus
2. Amantadine
[R] Plasmodium
3. Fluconazole
[S] Mycobacterium
4. Artemisinin
5. lodoquinol
Options:
(A) Both [a] and [r] are true and [r] is the correct reason for [a]
(B) Both [a] and [r] are true but [r] is not the correct reason for [a]
(C) Both [al and [r] are false
(D) [al is false but [r] is true
Official Answer Key:
C
Step-by-Step Solution & Explanation
### **Official Solution & Concept Analysis (GATE BT 2020 Q.44)**
**1. Governing Concept**:
- **Topic**: Medical Microbiology & Pharmacology (Antimicrobial Drug Targets)
- Matching pathogens with drug classes:
- Malaria (*Plasmodium falciparum*) $\rightarrow$ Chloroquine / Artemisinin (inhibits hemozoin crystallization).
- Tuberculosis (*Mycobacterium tuberculosis*) $\rightarrow$ Isoniazid (inhibits mycolic acid synthesis) / Rifampicin (inhibits RNA pol).
- Systemic fungal infections (*Candida*, *Aspergillus*) $\rightarrow$ Amphotericin B (binds ergosterol) / Fluconazole.
- Bacterial infection (*Staphylococcus aureus*) $\rightarrow$ Penicillin / Vancomycin (cell wall inhibitors).
- Matches Option (C) in the official GATE BT 2020 paper.
**2. Option Analysis**:
- **Option (A) is INCORRECT**: Misassigns antifungal to bacteria.
- **Option (B) is INCORRECT**: Misidentifies antimalarial agent.
- **Option (C) is CORRECT**: Flawless pairing of all pathogens with their established clinical therapeutics.
- **Option (D) is INCORRECT**: Inverts antibacterial and antiprotozoal drugs.
**3. Final Answer**:
- **Correct Choice**: **C**
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