GATE BT 2019 • Q14
MCQ • 1 Mark
Section 2: General Biotechnology
Biomolecules, enzyme kinetics
Subtopic: Fundamentals of Biomolecules, enzyme kinetics
Question Statement:
Which one of the following is a database of protein sequence motifs?
Options:
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(A) PROSITE
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(B) TrEMBL
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(C) SWISSPROT
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(D) PDB
Step-by-Step Solution & Explanation
### **Official Solution & Concept Analysis (GATE BT 2019 Q.14)**
**1. Governing Concept**:
- **Topic**: Bioinformatics & Protein Domain / Motif Databases
- Database classification:
- **PROSITE**: Comprehensive database of **protein sequence motifs, families, patterns, and profiles** (functional sites and signatures).
- **TrEMBL**: Translated EMBL nucleotide sequence database (unreviewed protein sequences).
- **Swiss-Prot**: Manually annotated, reviewed protein sequence database (UniProtKB).
- **PDB (Protein Data Bank)**: Primary archive for 3D atomic macromolecular structures solved by X-ray, NMR, Cryo-EM.
**2. Option Analysis**:
- **Option (A) [PROSITE] is CORRECT**: Dedicated database of biologically significant protein motifs, profiles, and active site signatures.
- **Option (B) [TrEMBL] is INCORRECT**: Raw translated sequence database.
- **Option (C) [SWISSPROT] is INCORRECT**: General curated sequence database.
- **Option (D) [PDB] is INCORRECT**: 3D structural coordinate database.
**3. Final Answer**:
- **Correct Choice**: **A**
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