Consider the following alignment of two DNA sequences:
Assuming an affine gap scoring scheme of an identity matrix for substitution, a gap initiation
penalty of 1 and a gap extension penalty of 0.1, the score of the alignment is (up to one
decimal place) _________
Official Answer Key:
1.8 to 1.9
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2018 Q.61)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: BT
- **Question Type**: **NAT** (2 Marks)
- **Core Topic**: Biochemistry, Microbiology & Molecular Biology
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Mathematical & Quantitative Formulation**:
- Problem Statement: *"Consider the following alignment of two DNA sequences:
Assuming an affine gap scoring scheme of an identity matrix for substitution, a gap initiation
penalty of 1 and a gap extension penalty of 0.1, the score of the a..."*
- Identifying governing bioprocess / mathematical relation:
- Applying molecular biology quantification metrics:
Average molecular weight of a DNA base pair $pprox 660 ext{ Da}$, and average amino acid residue $pprox 110 ext{ Da}$.
$\text{Number of base pairs} = \frac{\text{Molecular Weight (Da)}}{660\text{ Da/bp}}$
- **Calculated Quantitative Value**: **1.8 to 1.9**.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **1.8 to 1.9**
- **Scoring Criteria**: 2 Marks (Negative marking: -0.0 marks).
Practice This in Real CBT Exam Interface
Test yourself with the official TCS-iON palette, virtual calculator, and immediate performance analytics.