Subtopic: Fundamentals of Cell structure and signaling
Question Statement:
A humanized antibody is one in which the
Options:
(A) heavy and light chains are from human
(B) heavy chain is from human and light chain is from mouse
(C) light chain is from human and heavy chain is from mouse
(D) CDRs are from mouse, and the rest is from human
Official Answer Key:
D
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2012 Q.6)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: BT
- **Question Type**: **MCQ** (1 Mark)
- **Core Topic**: Quantitative & Analytical Aptitude
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"A humanized antibody is one in which the..."*
- **Option (D) [CORRECT]**: *"CDRs are from mouse, and the rest is from human"*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (A) [INCORRECT]**: *"heavy and light chains are from human"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (B) [INCORRECT]**: *"heavy chain is from human and light chain is from mouse"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (C) [INCORRECT]**: *"light chain is from human and heavy chain is from mouse"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **D**
- **Scoring Criteria**: 1 Mark (Negative marking: -0.33 marks).
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