Section 4: Bioprocess Engineering and Process Biotechnology
Bioreactor types, scale-up
Subtopic: Fundamentals of Bioreactor types, scale-up
Question Statement:
Match the downstream processes in Group I with the products in Group II.
Group I Group II
P. Solvent extraction 1. Lactic acid
Q. Protein-A linked affinity chromatography 2. Penicillin
R. Extractive distillation 3. Monoclonal antibody
S. Salting out 4. Lipase
(A) P-2, Q-3, R-1, S-4 (B) P-4, Q-1, R-2, S-3
(C) P-4, Q-1, R-3, S-2 (D) P-2, Q-4, R-1, S-3
Options:
(A) P-2, Q-3, R-1, S-4
(B) P-4, Q-1, R-2, S-3
(C) P-4, Q-1, R-3, S-2
(D) P-2, Q-4, R-1, S-3
Official Answer Key:
A
Step-by-Step Solution & Explanation
### **Official Solution & Step-by-Step Derivation (GATE BT 2012 Q.38)**
**1. Governing Concept & Syllabus Classification**:
- **Section**: BT
- **Question Type**: **MCQ** (2 Marks)
- **Core Topic**: Bioprocess Engineering
**2. Detailed Step-by-Step Analytical & Scientific Derivation**:
- **Systematic Conceptual & Option-by-Option Evaluation**:
- Problem Focus: *"Match the downstream processes in Group I with the products in Group II.
Group I Group II
P. Solvent extraction 1. Lactic acid
Q. Protein-A linked affinity chromatography 2. Penicillin
R. Extractive distillation ..."*
- **Option (A) [CORRECT]**: *"P-2, Q-3, R-1, S-4"*
- Validated by canonical biochemistry/biotechnology literature. Specifically matches the molecular mechanism, kinetic model, or empirical finding required.
- **Option (B) [INCORRECT]**: *"P-4, Q-1, R-2, S-3"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (C) [INCORRECT]**: *"P-4, Q-1, R-3, S-2"* does not satisfy the precise boundary conditions or molecular specificity.
- **Option (D) [INCORRECT]**: *"P-2, Q-4, R-1, S-3"* does not satisfy the precise boundary conditions or molecular specificity.
**3. Final Answer / Verification Summary**:
- **Official GATE Answer Key**: **A**
- **Scoring Criteria**: 2 Marks (Negative marking: -0.66 marks).
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